preconcentration and determination of mefenamic acid in pharmaceutical and biological fluid samples by polymer-grafted silica gel solid-phase extraction following high performance liquid chromatography
نویسندگان
چکیده
abstract mefenamic acid is a nonsteroidal anti-inflammatory drug (nsaid) that has analgesic,anti-infammatory and antipyretic actions. it is used to relieve mild to moderate pains. solid-phase extraction of mefenamic acid by a polymer grafted to silica gel is reported . poly allyl glycidyl ether/iminodiacetic acid-co-n, n-dimethylacrylamide was synthesized and grafted to silica gel and was used as an adsorbent for extraction of trace mefenamic acid in pharmaceutical and biological samples. different factors affecting the extraction method were investigated and optimum conditions were obtained. the optimum ph value for sorption of mefenamic acid was 4.0.the sorption capacity of grafted adsorbent was 7.0 mg/g. the best eluent solvent was found to be trifluoroacetic acid-acetic acid in methanol with a recovery of 99.6%. the equilibrium adsorption data of mefenamic acid by grafted silica gel was analyzed by langmuir model. the conformation of obtained data to langmuir isotherm model reveals the homogeneous binding sites of grafted silica gel surface. kinetic study of the mefenamic acid sorption by grafted silica gel indicates the good accessibility of the active sites in the grafted polymer. the sorption rate of the investigated mefenamic acid on the grafted silica gel was less than 5min.this novel synthesized adsorbent can be successfully applied for the extraction of trace mefenamic acid in human plasma, urine and pharmaceutical samples.
منابع مشابه
Preconcentration and Determination of Mefenamic Acid in Pharmaceutical and Biological Fluid Samples by Polymer-grafted Silica Gel Solid-phase Extraction Following High Performance Liquid Chromatography
Abstract Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that has analgesic,anti-infammatory and antipyretic actions. It is used to relieve mild to moderate pains. Solid-phase extraction of mefenamic acid by a polymer grafted to silica gel is reported . Poly allyl glycidyl ether/iminodiacetic acid-co-N, N-dimethylacrylamide was synthesized and grafted to silica gel and was used ...
متن کاملPreconcentration and Determination of Mefenamic Acid in Pharmaceutical and Biological Fluid Samples by Polymer-grafted Silica Gel Solid-phase Extraction Following High Performance Liquid Chromatography
Abstract Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that has analgesic,anti-infammatory and antipyretic actions. It is used to relieve mild to moderate pains. Solid-phase extraction of mefenamic acid by a polymer grafted to silica gel is reported . Poly allyl glycidyl ether/iminodiacetic acid-co-N, N-dimethylacrylamide was synthesized and grafted to silica gel and was used ...
متن کاملPreconcentration and Determination of Mefenamic Acid in Pharmaceutical and Biological Fluid Samples by Polymer-grafted Silica Gel Solid-phase Extraction Following High Performance Liquid Chromatography
Mefenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that has analgesic, anti-infammatory and antipyretic actions. It is used to relieve mild to moderate pains. Solid-phase extraction of mefenamic acid by a polymer grafted to silica gel is reported. Poly allyl glycidyl ether/iminodiacetic acid-co-N, N-dimethylacrylamide was synthesized and grafted to silica gel and was used as an ads...
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عنوان ژورنال:
iranian journal of pharmaceutical researchجلد ۱۴، شماره ۳، صفحات ۷۶۵-۷۷۳
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